J. O. Kotova, N. S. Osipova, J. A. Malinovskaya, P. A. Melnikov, S. E. Gelperina, “Properties of core–shell nanoparticles based on PLGA and human serum albumin prepared by different methods”, Mendeleev Commun., 2023, Volume 33, Issue 5,Pages <nobr>676

This article is cited in 3 papers

Communications

Properties of core–shell nanoparticles based on PLGA and human serum albumin prepared by different methods

J. O. Kotova^a, N. S. Osipova^a, J. A. Malinovskaya^ab, P. A. Melnikov^b, S. E. Gelperina^a

^a D.Mendeleev University of Chemical Technology of Russia, Moscow, Russian Federation
^b V.P. Serbsky National Medical Research Centre of Psychiatry and Narcology, Moscow, Russian Federation

Abstract: Core–shell nanoparticles with poly(lactide-co-glycolide) cores and human serum albumin shells (PLGA/HSA NPs) were prepared by three methods: by interfacial embedding of HSA in the PLGA NP surface during their formation and by adsorption or conjugation of HSA on pre-prepared PLGA NPs. All methods yielded PLGA/HSA NPs with a size of 130–150 nm and a narrow size distribution. In vitro fluorescence microscopy revealed the integrity of all core–shell systems when internalized in GL261 cells.

Keywords: core–shell nanoparticles, PLGA, human serum albumin, drug delivery systems, intracellular internalization, laser scanning confocal microscopy, LSCM.

Language: English

DOI: 10.1016/j.mencom.2023.09.027