V. N. Kalinin, I. L. Belyakova, V. V. Derunov, J. K. Park, H. Schmidhammer, “Synthesis and Properties of π-Complexes of Morphine Alkaloids with Palladium”, Mendeleev Commun., 1995, Volume 5, Issue 1,Pages <nobr>22

This article is cited in 8 papers

Synthesis and Properties of π-Complexes of Morphine Alkaloids with Palladium

V. N. Kalinin^a, I. L. Belyakova^a, V. V. Derunov^a, J. K. Park^b, H. Schmidhammer^c

^a A.N. Nesmeyanov Institute of Organoelement Compounds of Russian Academy of Sciences, Moscow, Russian Federation
^b Dong Kook Pharmaceutical Co., Ltd., Seoul, Korea
^c Institute of Pharmacy, University of Innsbruck, Innsbruck, Austria

Abstract: Treatment of 6β-chloro-6-deoxycodeine 1 with Pd(PPh₃)₄ yields 6-demethoxythebaine 2 and the π-allylic palladium complex 3, which further reacts with RZnX to give the cross-coupling product of the allylic ligand and R (compounds 5 and 6, respectively). The same products are formed upon reaction of 6β-chloro-6-deoxycodeine 1 with RZnX in the presence of catalytic amounts of Pd(PPh₃)₄.

Language: English

DOI: 10.1070/MC1995v005n01ABEH000443