Yu. A. Azev, H. Neunhoeffer, S. Foro, H. J. Lindner, S. V. Shorshnev, “Transformations of 6-Phenyl-1,2,4-triazine 4-Oxides in Reactions with Nucleophiles”, Mendeleev Commun., 1995, Volume 5, Issue 6,Pages <nobr>229

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Transformations of 6-Phenyl-1,2,4-triazine 4-Oxides in Reactions with Nucleophiles

Yu. A. Azev^a, H. Neunhoeffer^b, S. Foro^b, H. J. Lindner^b, S. V. Shorshnev^a

^a Ural Scientific Research Institute of Technology of Medical Preparations, Ekaterinburg, Russian Federation
^b Institute of Organic Chemistry, Technical University of Darmstadt, Darmstadt, Germany

Abstract: Reaction of 6-phenyl-1,2,4-triazine 4-oxide 1a with 1,3-dimethyluracil-6-hydrazones 2a–c in dimethylformamide in the presence of triethylamine affords the pyrazolo[3,4-d]pyrimidines 3a–c; under similar conditions 1,2,4-triazine 4-oxide 1b reacts with 1-phenyl-3-methylpyrazolone 7 to give the hydrazone derivative 8 and the dipyrazolylmethane derivative 9.

Language: English

DOI: 10.1070/MC1995v005n06ABEH000540