S. R. Golovash, A. V. Borodachev, M. E. Dmitriev, V. V. Ragulin, “N + PC strategy for the synthesis of phosphinic pseudopeptides incorporating glycine isostere”, Mendeleev Commun., 2023, Volume 33, Issue 6,Pages <nobr>784

This article is cited in 1 paper

Communications

N + PC strategy for the synthesis of phosphinic pseudopeptides incorporating glycine isostere

S. R. Golovash, A. V. Borodachev, M. E. Dmitriev, V. V. Ragulin

Institute of Physiologically Active Compounds, Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences, Chernogolovka, Moscow Region, Russian Federation

Abstract: The reaction between dialkyl methylenebiscarbamates and phosphonous carboxylic acids affords N-protected phosphinic pseudopeptides incorporating glycine isostere. The compounds obtained are promising building blocks for subsequent peptide modification.

Keywords: phosphinic pseudopeptides, dialkyl methylenebiscarbamates, phosphonous carboxylic acids, glycine isostere, amidoalkylation.

Language: English

DOI: 10.1016/j.mencom.2023.10.015

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