E. A. Dets, N. P. Iakimov, I. D. Grozdova, N. S. Melik-Nubarov, “L-Tyrosine-based biocompatible low-toxic substrate of peroxyoxalate chemiluminescent reaction”, Mendeleev Commun., 2023, Volume 33, Issue 6,Pages <nobr>793

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Communications

L-Tyrosine-based biocompatible low-toxic substrate of peroxyoxalate chemiluminescent reaction

E. A. Dets, N. P. Iakimov, I. D. Grozdova, N. S. Melik-Nubarov

Department of Chemistry, M.V. Lomonosov Moscow State University, Moscow, Russian Federation

Abstract: We synthesized a biocompatible substrate of the peroxy-oxalate chemiluminescent reaction on the basis of N-benzoyl-L-tyrosine ethyl ester. Its ability to interact with hydrogen peroxide was evaluated by light emission in the presence of a perylene activator. Its cytotoxicity is three times less than that of bis[2,4,5-trichloro-6-(pentyloxycarbonyl)phenyl] oxalate (CPPO).

Keywords: peroxyoxalate chemiluminescent reaction, poly-L-lactide–PEG amphiphilic copolymers, L-tyrosine, bis[2,4,5-trichloro-6-(pentyloxycarbonyl)phenyl] oxalate, chemo-induced PDT, micelles.

Language: English

DOI: 10.1016/j.mencom.2023.10.018

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