B. A. Cheskis, I. G. Alekseev, A. M. Moiseenkov, “Total Synthesis of the Archaebacterial C40-Diol and its Enantiomer Based on(R)-5-Acetoxy-4-methylpentanoic Acid”, Mendeleev Commun., 1993, Volume 3, Issue 3,Pages 93

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Total Synthesis of the Archaebacterial C₄₀-Diol and its Enantiomer Based on(R)-5-Acetoxy-4-methylpentanoic Acid

B. A. Cheskis, I. G. Alekseev, A. M. Moiseenkov

N.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow, Russian Federation

Abstract: Optically pure archaebacterial C₄₀-diol 2a and its enantiomer 2b have been synthesized in 17 steps and ca. 2% overall yield using a readily available (R)-5-acetoxy-4-methylpentanoic acid as the single chiral building block.

Language: English

DOI: 10.1070/MC1993v003n03ABEH000238