V. I. Vysokov, V. N. Charushin, G. B. Afanasyeva, O. N. Chupakhin, “The Synthesis of Fluorinated 4<i>H</i>-1,4-Benzothiazine-2-carboxylic Acid 1,1-Dioxides—Thionated Analogues of Pefloxacin”, Mendeleev Commun., 1993, Volume 3, Issue 4,Pages <nobr>159–160</nobr>

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Mendeleev Commun., 1993 Volume 3, Issue 4, Pages 159–160 (Mi mendc5310)

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The Synthesis of Fluorinated 4H-1,4-Benzothiazine-2-carboxylic Acid 1,1-Dioxides—Thionated Analogues of Pefloxacin

V. I. Vysokov^a, V. N. Charushin^b, G. B. Afanasyeva^a, O. N. Chupakhin^c

^a Department of Technology of Organic Synthesis, Urals State Technical University, Ekaterinburg, Russian Federation
^b Department of Organic Chemistry, Urals State Technical University, Ekaterinburg, Russian Federation
^c I. Ya. Postovsky Institute of Organic Synthesis, Urals Branch of the Russian Academy of Sciences, Ekaterinburg, Russian Federation

Abstract: A synthetic route to 1,4-benzothiazine-2-carboxylic acid 1,1 -dioxides, analogues of the ‘fluoroquinolone’ family of antibacterials, has been developed; unfortunately, the target compound (the thia-analogue of pefloxacin) has not revealed remarkable antibacterial activity in vitro against the majority of the strains tested.

Language: English

DOI: 10.1070/MC1993v003n04ABEH000267

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