A. Yu. Lokova, A. Yu. Rosova, I. G. Panova, N. G. Loiko, Yu. A. Nikolaev, A. A. Yaroslavov, “Molecular weight of polyanion affects the biological activity of interpolycomplexes”, Mendeleev Commun., 2024, Volume 34, Issue 1,Pages <nobr>97

Communications

Molecular weight of polyanion affects the biological activity of interpolycomplexes

A. Yu. Lokova^a, A. Yu. Rosova^b, I. G. Panova^a, N. G. Loiko^c, Yu. A. Nikolaev^c, A. A. Yaroslavov^a

^a Department of Chemistry, M.V. Lomonosov Moscow State University, Moscow, Russian Federation
^b M.V. Lomonosov Institute of Fine Chemical Technologies, MIREA - Russian Technological University, Moscow, Russian Federation
^c Federal Research Centre 'Fundamentals of Biotechnology' of the Russian Academy of Sciences, Moscow, Russian Federation

Abstract: Cationic poly(diallyldimethylammonium chloride) forms nonstoichiometric positively charged interpolyelectrolyte complexes (IPECs) with short- and long-chain anionic sodium polyacrylate. When added to anionic liposomes, the short-chain polyanion IPECs dissociate and the free polycation binds to the liposomes, whereas the long-chain polyanion IPECs bind to the liposomes as a whole. These results correlate with the antimicrobial activity of IPECs, thereby highlighting the important role of polymer molecular weight in the cellular response to IPEC binding.

Keywords: polycation, polyanion, polycomplex, liposomes, complexation, antimicrobial activity.

Language: English

DOI: 10.1016/j.mencom.2024.01.029

	*Supplementary materials:*
		Supplementary_data_1.pdf	145.7 Kb