O. E. Nasakin, E. S. Ivanova, M. A. Maryasov, V. V. Andreeva, S. V. Karpov, O. A. Lodochnikova, D. Yu. Grishaev, “3,3,4,4-Tetracyanoalkanones as expedient reagents for utilization of N,N-dimethylhydrazine”, Mendeleev Commun., 2023, Volume 33, Issue 6,Pages 856

Communications

3,3,4,4-Tetracyanoalkanones as expedient reagents for utilization of N,N-dimethylhydrazine

O. E. Nasakin^a, E. S. Ivanova^a, M. A. Maryasov^a, V. V. Andreeva^a, S. V. Karpov^a, O. A. Lodochnikova^b, D. Yu. Grishaev^c

^a Department of Chemistry, I.N. Ulyanov Chuvash State University, Cheboksary, Russian Federation
^b A.E. Arbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center of the Russian Academy of Sciences, Kazan, Russian Federation
^c Pharmacy Research & Education Center, Kazan Federal University, Kazan, Russian Federation

Abstract: To utilize N,N-dimethylhydrazine, the corresponding +formaldehyde hydrazone was reacted with 1,1,2,2-tetra-cyanoethane or 3,3,4,4-tetracyanoalkanones. The first process yielded 5-amino-1-dimethylamino-1,2-dihydro-3H-pyrrole-3,3,4-tricarbonitrile while the second afforded pyrrolo[3,4-c]quinolone multifunctional derivatives. These resultant products hold promise in molecular design and pharmaceutical chemistry.

Keywords: N,N-dimethylhydrazine, formaldehyde dimethylhydrazone, tetracyanoethylene, 3,3,4,4-tetracyanoalkanones, Thorpe–Ziegler type cyclization, 1,2-dihydro-3H-pyrrole-3,3,4-tricarbonitriles, 4,5-dihydro-1H-pyrrolo[3,4-c]pyridine-3a,7a-dicarbonitriles.

Language: English

DOI: 10.1016/j.mencom.2023.10.039

	*Supplementary materials:*
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