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JOURNALS // Mendeleev Communications // Archive

Mendeleev Commun., 2025 Volume 35, Issue 4, Pages 454–456 (Mi mendc5563)

Communications

Synthesis of daidzein derivatives for targeted drug delivery

A. I. Sidorova, V. S. Koval, V. V. Kulikova, S. V. Revtovich, E. A. Morozova, A. A. Stomakhin, N. V. Anufrieva, P. N. Solyev

V. A. Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, Russian Federation

Abstract: A new protocol was developed for the synthesis of daidzein derivatives bearing 7-positioned linkers with carboxy and amino functions. The key step of the scheme is the Suzuki cross-coupling, the optimized procedures provide high yields and do not require chromatographic purification. This approach is advantageous for further linker elongation necessary for anchoring and drug-coupling; the compounds obtained are regarded as tumor-directing carriers.

Keywords: isoflavones, Suzuki cross-coupling, chromatography-free isolation, targeted drug delivery, daidzein, estrogen receptor α.

Received: 09.01.2025
Accepted: 10.03.2025

Language: English

DOI: 10.71267/mencom.7722



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© Steklov Math. Inst. of RAS, 2025