M. G. Chernysheva, T. Shen, I. S. Chaschin, G. A. Badun, V. G. Vasil'ev, I. V. Mikheev, N. P. Bakuleva, “Nanodiamond–drug conjugates for coating xenogenic heart valve prostheses”, Mendeleev Commun., 2024, Volume 34, Issue 1,Pages <nobr>104

This article is cited in 2 papers

Communications

Nanodiamond–drug conjugates for coating xenogenic heart valve prostheses

M. G. Chernysheva^a, T. Shen^a, I. S. Chaschin^bc, G. A. Badun^a, V. G. Vasil'ev^b, I. V. Mikheev^a, N. P. Bakuleva^c

^a Department of Chemistry, M.V. Lomonosov Moscow State University, Moscow, Russian Federation
^b A.N. Nesmeyanov Institute of Organoelement Compounds of Russian Academy of Sciences, Moscow, Russian Federation
^c A.N. Bakulev National Medical Research Centre of Cardiovascular Surgery, Moscow, Russian Federation

Abstract: Multicomponent coatings of collagen-rich matrices of bovine pericardium were prepared from nanodiamonds and antibiotics, namely, amikacin, levofloxacin and chitosan. Preservation of the multilayers that consist of nanodiamonds, antimicrobial agents and chitosan on the material surface and preventing the calcification of the material were revealed.

Keywords: xenogenic heart valve prostheses, nanodiamonds, chitosan, amikacin, levofloxacin, calcification.

Language: English

DOI: 10.1016/j.mencom.2024.01.031

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