M. E. Kukushkin, N. A. Karpov, D. E. Shybanov, N. V. Zyk, E. K. Beloglazkina, “A convenient synthesis of 3-aryl-5-methylidene-2-thiohydantoins”, Mendeleev Commun., 2022, Volume 32, Issue 1,Pages <nobr>126

This article is cited in 8 papers

Communications

A convenient synthesis of 3-aryl-5-methylidene-2-thiohydantoins

M. E. Kukushkin^ab, N. A. Karpov^a, D. E. Shybanov^a, N. V. Zyk^a, E. K. Beloglazkina^a

^a Department of Chemistry, M.V. Lomonosov Moscow State University, Moscow, Russian Federation
^b National University of Science and Technology 'MISIS', Moscow, Russian Federation

Abstract: 3-Aryl-5-methylidene-2-thiohydantoins were constructed in one-pot reaction of aryl isothiocyanates and 3-morpholino- alanine in alkaline medium with the subsequent treatment with boiling hydrochloric acid.

Keywords: 2-thiohydantoins, exocyclic C=C bond, heterocyclization, isothiocyanates, amino acids.

Language: English

DOI: 10.1016/j.mencom.2022.01.041

	*Supplementary materials:*
		Supplementary_data_1.pdf	3.8 Mb