N. A. Zefirov, A. Glassl, E. V. Radchenko, A. N. Borovik, V. V. Stanishevskiy, E. R. Milaeva, S. A. Kuznetsov, O. N. Zefirova, “Podophyllotoxin esters with alicyclic residues: an insight into the origin of microtubule-curling effect in cancer cells”, Mendeleev Commun., 2022, Volume 32, Issue 2,Pages <nobr>173

This article is cited in 9 papers

Communications

Podophyllotoxin esters with alicyclic residues: an insight into the origin of microtubule-curling effect in cancer cells

N. A. Zefirov^a, A. Glassl^b, E. V. Radchenko^a, A. N. Borovik^a, V. V. Stanishevskiy^a, E. R. Milaeva^a, S. A. Kuznetsov^b, O. N. Zefirova^a

^a Department of Chemistry, M.V. Lomonosov Moscow State University, Moscow, Russian Federation
^b Institute of Biological Sciences, Cell Biology and Biosystems Technology, University of Rostock, Rostock, Germany

Abstract: Immunofluorescent microscopy of cancer cells A549 treated with novel alicyclic (mostly bridged) podophyllotoxin C⁴-esters at different concentrations gave evidence that the ‘curling’ of microtubules occurred at one of the first steps of their depolymerisation. Molecular dynamics study revealed the differences in curved conformations of tubulin dimer in a complex with adamantane-comprising ester and in a complex with podophyllotoxin.

Keywords: Molecular dynamics, Podophyllotoxin, Alicyclic compounds, Esters, Bridged moieties, Tubulin, Microtubules, Human lung carcinoma A549, Immunofluorescence microscopy.

Language: English

DOI: 10.1016/j.mencom.2022.03.006

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