P. Paramonova, T. Sharonova, S. A. Kalinin, E. G. Chupakhin, A. S. Bunev, M. Yu. Krasavin, “(E)-3-Arylidene-4-diazopyrrolidine-2,5-diones conveniently elaborated into cytotoxic compounds bearing primary sulfonamide and Michael acceptor moieties”, Mendeleev Commun., 2022, Volume 32, Issue 2,Pages <nobr>176

This article is cited in 2 papers

Communications

(E)-3-Arylidene-4-diazopyrrolidine-2,5-diones conveniently elaborated into cytotoxic compounds bearing primary sulfonamide and Michael acceptor moieties

P. Paramonova^a, T. Sharonova^a, S. A. Kalinin^ab, E. G. Chupakhin^ac, A. S. Bunev^b, M. Yu. Krasavin^ac

^a Institute of Chemistry, St. Petersburg State University, St. Petersburg, Russian Federation
^b Medicinal Chemistry Centre, Togliatti State University, Togliatti, Russian Federation
^c Immanuel Kant Baltic Federal University, Kaliningrad, Russian Federation

Abstract: The earlier described (E)-3-arylidene-4-diazopyrrolidine-2,5-diones have been elaborated into two distinct series of compounds both bearing a primary sulfonamide moiety and an electrophilic ‘Michael acceptor’ motif. These compounds demonstrated cytotoxicity against colorectal cancer cell line HCT 116.

Keywords: Rhodium catalysis, Diazo coupling, Sulfonamides, Michael acceptors, Enzyme inhibitors, MTT assay, Cell viability, Anti-proliferative agents.

Language: English

DOI: 10.1016/j.mencom.2022.03.007

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