N. Yu. Zyk, A. Yu. Kolchanova, N. S. Volkova, A. A. Uspenskaia, D. A. Skvortsov, E. K. Beloglazkina, N. V. Zyk, A. G. Majouga, A. E. Machulkin, “A novel molecular platform for co-delivery of monomethyl auristatin E and ispinesib to prostate cancer cells”, Mendeleev Commun., 2025, Volume 35, Issue 4,Pages <nobr>440

Communications

A novel molecular platform for co-delivery of monomethyl auristatin E and ispinesib to prostate cancer cells

N. Yu. Zyk^a, A. Yu. Kolchanova^a, N. S. Volkova^a, A. A. Uspenskaia^a, D. A. Skvortsov^a, E. K. Beloglazkina^a, N. V. Zyk^a, A. G. Majouga^b, A. E. Machulkin^ac

^a Department of Chemistry, M. V. Lomonosov Moscow State University, 119991 Moscow, Russian Federation
^b D. I. Mendeleev University of Chemical Technology of Russia, 125047 Moscow, Russian Federation
^c Peoples Friendship University of Russia (RUDN University), 117198 Moscow, Russian Federation

Abstract: A conjugate for co-delivery of ispinesib and monomethyl auristatin E was prepared using methods of peptide synthesis and azide–alkyne cycloaddition. Cytotoxicity studies of the mentioned drug pair were performed. In vitro studies of the synthesized bimodal conjugate were conducted on prostate cancer cell lines.

Keywords: prostate cancer, prostate specific membrane antigen, bimodal conjugates, monomethyl auristatin E, ispinesib, peptide synthesis, azide–alkyne cycloaddition.

Received: 21.10.2024
Accepted: 05.12.2024

Language: English

DOI: 10.71267/mencom.7661

	*Supplementary materials:*
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