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JOURNALS // Mendeleev Communications // Archive
Mendeleev Commun., 2025 Volume 35, Issue 4, Pages 472–474 (Mi mendc6335)
Communications

Hydroxycarbonylation of vinyl acetate with formic acid: pathway to lactic acid and lactates

O. L. Eliseev, T. N. Bondarenko, M. V. Tsapkina

N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 119991 Moscow, Russian Federation

Abstract: The Pd-catalyzed hydroxycarbonylation of vinyl acetate in the presence of formic acid into 2-acetoxypropionic acid is reported. The reaction proceeds chemo- and regioselectively under very mild conditions of 80 °C and 3–6 bar CO.

Keywords: hydroxycarbonylation, palladium, carbon monoxide, formic acid, vinyl acetate, acetoxypropionic acid.

Received: 16.10.2024
Accepted: 27.12.2024

Language: English

DOI: 10.71267/mencom.7657



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© Steklov Math. Inst. of RAS, 2025