L. Wang, D. Wang, J. Tang, “An efficient solvent-free thiocyanation of indoles by grinding”, Mendeleev Commun., 2025, Volume 35, Issue 3,Pages <nobr>269

Communications

An efficient solvent-free thiocyanation of indoles by grinding

L. Wang, D. Wang, J. Tang

School of Chemical and Pharmaceutical Engineering, Changzhou Vocational Institute of Engineering, 213164 Changzhou, P. R. China

Abstract: An efficient thiocyanation of indoles by grinding with ammonium thiocyanate and hypervalent iodine reagents under solvent-free conditions has been developed. The reaction proceeded rapidly to provide the target 3-thiocyanatoindoles in 75–86% yields.

Keywords: thiocyanation, grinding, solvent-free, indole, hypervalent iodine(III) reagent, ammonium thiocyanate.

Received: 07.11.2024
Accepted: 06.12.2024

Language: English

DOI: 10.71267/mencom.7677

	*Supplementary materials:*
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