A. A. Druzina, N. V. Dudarova, O. B. Zhidkova, I. A. Razumov, O. I. Solovieva, V. V. Kanygin, V. I. Bregadze, “Synthesis and cytotoxicity of novel cholesterol–cobalt bis(dicarbollide) conjugates”, Mendeleev Commun., 2022, Volume 32, Issue 3,Pages <nobr>354

This article is cited in 3 papers

Communications

Synthesis and cytotoxicity of novel cholesterol–cobalt bis(dicarbollide) conjugates

A. A. Druzina^a, N. V. Dudarova^a, O. B. Zhidkova^a, I. A. Razumov^b, O. I. Solovieva^b, V. V. Kanygin^c, V. I. Bregadze^a

^a A.N. Nesmeyanov Institute of Organoelement Compounds of Russian Academy of Sciences, Moscow, Russian Federation
^b Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russian Federation
^c Novosibirsk State University, Novosibirsk, Russian Federation

Abstract: The novel conjugates of cholesterol with cobalt – bis(dicarbollide) were synthesized by the ring-opening reactions of the cyclic oxonium derivatives of [3,3′-Co(C₂B₉H₁₁)₂]^– with the OH group of cholesterol 2-hydroxyethyl ether. The compounds obtained were tested for toxicity to glioblastoma U-87 MG cells and human embryo fibroblasts FECH-15 cells

Keywords: boron neutron capture therapy, cancer, boron cage, cobalt bis(dicarbollide), cholesterol, liposomes, lipids, cytotoxicity, human glioblastoma U-87 MG.

Language: English

DOI: 10.1016/j.mencom.2022.05.021

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