Mendeleev Commun., 2022 Volume 32, Issue 3, Pages 357–359
(Mi mendc663)
This article is cited in
3 papers
Communications Synthesis and in vitro antifungal activity of selenium-containing chitin derivatives A. R. Egorov a ,
N. Z. Yagafarov ab ,
A. A. Artemjev a ,
O. Khubiev a ,
B. Medjbour a ,
V. A. Kozyrev a ,
N. D. Sikaona a ,
O. I. Tsvetkova a ,
V. V. Rubanik c ,
V. V. Rubanik c ,
A. V. Kurliuk d ,
T. V. Shakola d ,
N. N. Lobanov a ,
I. S. Kritchenkov ace ,
A. G. Tskhovrebov a ,
A. A. Kirichuk a ,
V. N. Khrustalev af ,
A. S. Kritchenkov ac a Peoples Friendship University of Russia (RUDN University), Moscow, Russian Federation b N.I. Pirogov Russian National Research Medical University, Moscow, Russian Federation c Institute of Technical Acoustics, National Academy of Sciences of Belarus, Vitebsk, Republic of Belarus
d Vitebsk State Medical University, Vitebsk, Republic of Belarus
e St. Petersburg State University, St. Petersburg, Russian Federation f N.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow, Russian Federation Abstract:
Mild and ‘green’ ultrasound-assisted reaction of chitin with 3-(chloromethyl)[1,2,4]selenadiazolo[4,5-
a ]pyridin-4-ium bromide in water affords novel selenium-containing cationic chitin derivatives. The thus obtained chitin derivatives are water soluble and are characterized by high
in vitro antifungal activity comparable with conventional antifungal drug Amphotericin B.
Keywords:
organoselenium compounds, chitin, alkylation, [1,2,4]selenadiazolo[4,5-a ]pyridin-4-ium salts, ultrasound, antifungal activity.
Language: English
DOI:
10.1016/j.mencom.2022.05.022
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