N. M. Chobanov, L. U. Dzhemileva, K. O. Vakhnin, U. M. Dzhemilev, V. A. D’yakonov, “Synthesis and antitumor activity of bis-camptothecin ester of succinic acid”, Mendeleev Commun., 2025, Volume 35, Issue 3,Pages <nobr>289

Communications

Synthesis and antitumor activity of bis-camptothecin ester of succinic acid

N. M. Chobanov^a, L. U. Dzhemileva^a, K. O. Vakhnin^b, U. M. Dzhemilev^a, V. A. D’yakonov^a

^a N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 119991 Moscow, Russian Federation
^b Institute of Physiologically Active Compounds, Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences, 142432 Chernogolovka, Moscow Region, Russian Federation

Abstract: New succinic diester containing two residues of antitumor alkaloid camptothecin has been synthesized. Its cytotoxicity and effect on cell cycle and induction of apoptosis were explored using modern methods of flow cytometry, as well as in vitro studies of the inhibitory activity against human topoisomerase I.

Keywords: camptothecin, succinic diester, hybrid molecules, cytotoxicity, cell cycle, apoptosis, topoisomerase I inhibitors, antitumor activity, flow cytometry.

Received: 09.10.2024
Accepted: 05.12.2024

Language: English

DOI: 10.71267/mencom.7641

	*Supplementary materials:*
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