S. N. Sirakanyan, E. K. Hakobyan, D. Spinelli, A. Geronikaki, V. G. Kartsev, H. A. Yegoryan, A. A. Hovakimyan, “Synthesis of new heterocyclic systems fused at pyrazolo[3,4-<i>c</i>]-2,7-naphthyridine core”, Mendeleev Commun., 2022, Volume 32, Issue 3,Pages <nobr>393

Communications

Synthesis of new heterocyclic systems fused at pyrazolo[3,4-c]-2,7-naphthyridine core

S. N. Sirakanyan^a, E. K. Hakobyan^a, D. Spinelli^b, A. Geronikaki^c, V. G. Kartsev^d, H. A. Yegoryan^a, A. A. Hovakimyan^a

^a Scientific Technological Center of Organic and Pharmaceutical Chemistry, National Academy of Sciences of the Republic of Armenia, Yerevan, Armenia
^b Dipartimento di Chimica ''G. Ciamician'', Universita degli Studi di Bologna, Bologna, Italy
^c Department of Chemical Engineering, Aristotle University of Thessaloniki, Thessaloniki, Greece
^d 'InterBioScreen Ltd.', Chernogolovka, Moscow Region, Russian Federation

Abstract: Efficient syntheses of new heterocyclic systems comprising pyrimido[1',2':1,5]pyrazolo[3,4-c]-2,7-naphthyridine, pyrazolo[3,4-c][1,2,4]triazolo[3,4-a]-2,7-naphthyridine and pyrazolo[3,4-c]tetrazolo[5,1-a]-2,7-naphthyridine cores were performed in two simple steps. In the first step, pyrazole ring was fused at the 2-chloro-3-cyanopyridine moiety by treatment with hydrazine. In the second step, pyrimidine part was fused at the thus formed 3-aminopyrazole moiety by heterocyclization with acetylacetone.

Keywords: 2,7-naphthyridines, pyrimido[1' 2':1,5]pyrazolo[3,4-c]-2,7-naphthyridine, pyrazolo[3,4-c][1,2,4]triazolo[3,4-a]-2,7- naphthyridines, pyrazolo[3,4-c]tetrazolo[5,1-a]-2,7-naphthyridine, heterocyclization, hydrazine, acetylacetone.

Language: English

DOI: 10.1016/j.mencom.2022.05.034

	*Supplementary materials:*
		Supplementary_data_1.pdf	8.8 Mb