M. Yu. Krasavin, A. A. Shetnev, V. A. Panova, S. A. Ivanovskii, S. A. Kalinin, T. Vinogradova, V. V. Sharoyko, P. Yablonsky, “Hetaryl- and heteroarylvinyl-substituted nitrofurans identified as non-cytotoxic selective antitubercular agents”, Mendeleev Commun., 2022, Volume 32, Issue 4,Pages <nobr>452

This article is cited in 4 papers

Communications

Hetaryl- and heteroarylvinyl-substituted nitrofurans identified as non-cytotoxic selective antitubercular agents

M. Yu. Krasavin^a, A. A. Shetnev^b, V. A. Panova^b, S. A. Ivanovskii^b, S. A. Kalinin^a, T. Vinogradova^c, V. V. Sharoyko^a, P. Yablonsky^c

^a Institute of Chemistry, St. Petersburg State University, St. Petersburg, Russian Federation
^b K. D. Ushinsky Yaroslavl State Pedagogical University, Yaroslavl, Russian Federation
^c St. Petersburg Research Institute of Phthisiopulmonology, St. Petersburg, Russian Federation

Abstract: New (E)-5-[2-(5-nitrofuran-2-yl)vinyl]-1,2,4-oxadiazoles and 5-(5-nitrofuran-2-yl)-1,2,4-oxadiazoles were synthesized via the base-promoted condensation of nitrofuran-containing acyl chlorides with amidoximes. Testing these compounds against Gram-negative E. coli, Gram-positive B. subtilis and S. aureus as well as M. tuberculosis HRv37 strain revealed three compounds being selectively antimycobacterial. None of these compounds displayed any cytotoxicity towards human pancreatic epithelioid carcinoma cell line, PANC-1.

Keywords: nitrofurans, 124-oxadiazoles, amidoximes, olefin linker, direct bond, antibacterial assay, antimycobacterial assay, MTT assay, cell viability.

Language: English

DOI: 10.1016/j.mencom.2022.07.008

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