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JOURNALS // Mendeleev Communications // Archive
Mendeleev Commun., 2025 Volume 35, Issue 1, Pages 99–101 (Mi mendc7)
Communications

One-pot synthesis of functionalized dihydroindolizinones from pyrrolylpropynoates and diethyl aminomalonate

M. D. Gotsko, I. V. Saliy, I. A. Ushakov, L. N. Sobenina, B. A. Trofimov

A. E. Favorsky Irkutsk Institute of Chemistry, Siberian Branch of the Russian Academy of Sciences, 664033 Irkutsk, Russian Federation

Abstract: 3-(Pyrrol-2-yl)propynoates react with diethyl aminomalonate hydrochloride (excess Cs2CO3, reflux in MeCN, 6 h) to chemoselectively afford 8-amino-4-oxo-5,6-dihydroindolizine-7-carboxylates in good yields (62–85%).

Keywords: pyrrolylpropynoates, diethyl aminomalonate, dihydroindolizinones, nucleophilic addition, base, tetrahydroindolecarboxylate.

Received: 21.06.2024
Accepted: 06.08.2024

Language: English

DOI: 10.71267/mencom.7547


© Steklov Math. Inst. of RAS, 2025