K. E. Shepelenko, K. A. Nikolaeva, I. G. Gnatiuk, O. G. Garanzha, A. A. Alexandrov, M. E. Minyaev, V. M. Chernyshev, “Ruthenium(II)-catalyzed C(3)–H arylation of furan moiety in fuberidazole derivatives”, Mendeleev Commun., 2022, Volume 32, Issue 4,Pages <nobr>485

This article is cited in 7 papers

Communications

Ruthenium(II)-catalyzed C(3)–H arylation of furan moiety in fuberidazole derivatives

K. E. Shepelenko^a, K. A. Nikolaeva^a, I. G. Gnatiuk^a, O. G. Garanzha^a, A. A. Alexandrov^a, M. E. Minyaev^b, V. M. Chernyshev^a

^a Platov South-Russian State Polytechnic University, Novocherkassk, Russian Federation
^b N.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow, Russian Federation

Abstract: An efficient selective C(3)–H arylation of furan ring in 2-(furan-2-yl)benzimidazoles, derivatives of fuberidazole fungicide, with aryl bromides catalyzed by [RuCl₂(cymene)]₂/ pivalic acid system has been accomplished. High selectivity of the process may be accounted for by the action of benzimidazol-2-yl substituent as the directing group.

Keywords: furans, CH-functionalization, arylation, ruthenium complexes, carboxylate assistance, 2-hetarylfurans, benzimidazoles.

Language: English

DOI: 10.1016/j.mencom.2022.07.018

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