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JOURNALS // Mendeleev Communications // Archive

Mendeleev Commun., 2025 Volume 35, Issue 3, Pages 241–248 (Mi mendc7258)

Focus Article

Pyrrolo[1,2-b]pyridazines: synthesis and application perspective

E. Yu. Mendograloa, R. O. Shcherbakovab, L. N. Sorotskajac, M. G. Uchuskinab

a Perm State University, 614990 Perm, Russian Federation
b Perm Federal Scientific Centre, Institute of Technical Chemistry, Ural Branch of the Russian Academy of Sciences, 614013 Perm, Russian Federation
c Kuban State Technological University, 350072 Krasnodar, Russian Federation

Abstract: Pyrrolo[1,2-b]pyridazines continue to attract significant interest due to their diverse biological activities. This review explores various synthetic approaches to constructing the pyrrolo[1,2-b]pyridazine scaffold and examines its applications. Covering key advancements in pyrrolo[1,2-b]pyridazine chemistry reported between 2008 and 2024, we highlight their role in the development of practically relevant compounds. By emphasizing recent progress in this field, we aim to inspire further research and innovation in the synthesis and application of these heterocyclic systems.

Keywords: pyrrole, pyridazine, pyrrolo[1,2-b]pyridazines, synthetic methodology, cyclization, 1,3-dipolar cycloaddition

Received: 18.02.2025
Accepted: 12.03.2025

Language: English

DOI: 10.71267/mencom.7749



© Steklov Math. Inst. of RAS, 2025