O. V. Shabalina, D. A. Shabalin, “Unveiling an underestimated potential of vanillin-derived alkynes: synthesis of highly functionalized 3(2<em>H</em>)-furanone with antiradical activity”, Mendeleev Commun., 2025, Volume 35, Issue 5,Pages <nobr>609

Communications

Unveiling an underestimated potential of vanillin-derived alkynes: synthesis of highly functionalized 3(2H)-furanone with antiradical activity

O. V. Shabalina^a, D. A. Shabalin^b

^a Irkutsk State University, 664003 Irkutsk, Russian Federation
^b A. E. Favorsky Irkutsk Institute of Chemistry, Siberian Branch of the Russian Academy of Sciences, 664033 Irkutsk, Russian Federation

Abstract: Target-oriented synthesis of highly functionalized 3(2H)-furanone from vanillin through several alkyne intermediates was realized in six steps. The title compound bearing two 4-hydroxy-3-methoxyphenyl moieties showed antiradical activity 1.54 times higher compared to Trolox.

Keywords: vanillin, alkynes, acetylenic ketones, 3(2H)-furanones, radical scavenging activity.

Received: 16.01.2025
Accepted: 13.03.2025

Language: English

DOI: 10.71267/mencom.7727

	*Supplementary materials:*
		Supplementary_data_1.pdf	1.1 Mb