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Mendeleev Commun., 2025 Volume 35, Issue 5, Pages 606–608 (Mi mendc7290)

Communications

5-Amino-1,2,4-triazole-3-carboxamide homologues and their biological potential

E. S. Oleynika, A. A. Shmarinaa, E. R. Mitinaa, E. A. Mikhinaa, I. A. Semenova, E. D. Savinaab, L. E. Grebenkinaa, E. M. Zhidkovab, E. A. Lesovayabcd, E. N. Vetrovae, O. N. Sinevaf, A. V. Matveeva

a M. V. Lomonosov Institute of Fine Chemical Technologies, MIREA – Russian Technological University, 119571 Moscow, Russian Federation
b N. N. Blokhin National Medical Research Center of Oncology, 115478 Moscow, Russian Federation
c Peoples’ Friendship University of Russia (RUDN University), 117198 Moscow, Russian Federation
d I. P. Pavlov Ryazan State Medical University, 390026 Ryazan, Russian Federation
e N. F. Gamaleya National Research Center of Epidemiology and Microbiology, 123098 Moscow, Russian Federation
f G. F. Gause Institute of New Antibiotics, 119021 Moscow, Russian Federation

Abstract: New homologues of 5-amino-1,2,4-triazole-3-carboxamide, viz., 5-(ω-aminoalkyl)-1,2,4-triazole-3-carboxamides have been synthesized. The intermediate acyloxalamidrazones undergo thermal cyclization to 1,2,4-triazoles with the better yield in the absence of catalyst while in the presence of 10 mol% TsOH the main product is the corresponding 1,3,4-oxadiazole derivative. The obtained compounds have demonstrated various biological properties comparable to those of the nucleoside drug ribavirin.

Keywords: 5-(ω-aminoalkyl)-1,2,4-triazole-3-carboxamides, 1,2,4-triazole-3-carboxylic acid derivatives, acyloxalamidrazones, antiviral agents, acute lymphoblastic leukemia, chronic myeloid leukemia, antimicrobial properties.

Received: 26.02.2025
Accepted: 07.04.2025

Language: English

DOI: 10.71267/mencom.7753



© Steklov Math. Inst. of RAS, 2025