V. B. Kharitonov, O. G. Chusova, I. O. Bekshaite, K. A. Vasiliev, A. N. Rodionov, Yu. V. Nelyubina, P. V. Dorovatovskii, D. A. Loginov, “Rhodium(III)-catalyzed C–H annulation for the construction of antifungal agents based on isocoumarin framework”, Mendeleev Commun., 2025, Volume 35, Issue 5,Pages <nobr>602

This article is cited in 1 paper

Communications

Rhodium(III)-catalyzed C–H annulation for the construction of antifungal agents based on isocoumarin framework

V. B. Kharitonov^a, O. G. Chusova^a, I. O. Bekshaite^a, K. A. Vasiliev^a, A. N. Rodionov^a, Yu. V. Nelyubina^ab, P. V. Dorovatovskii^c, D. A. Loginov^a

^a A. N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, 119334 Moscow, Russian Federation
^b Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences, 142432 Chernogolovka, Moscow Region, Russian Federation
^c National Research Centre ‘Kurchatov Institute’, 123182 Moscow, Russian Federation

Abstract: A series of hydroxy- and alkoxy-substituted isocoumarins were synthesized in one step by the rhodium-catalyzed C–H annulation of benzoic acids with alkynes. 8,9-Diethyl-6H-[1,3]dioxolo[4,5-f]isochromen-6-one and its isoquinolone analog have effectively inhibited the growth of six types of phytopathogenic fungi at 30 mg dm^–3 concentration, the activity exceeding that of the commercial Triadimefon.

Keywords: antifungal agents, C–H activation, C–H annulation, isocoumarins, benzoic acids, alkynes, homogeneous catalysis, rhodium complexes.

Received: 21.04.2025
Accepted: 28.04.2025

Language: English

DOI: 10.71267/mencom.7777

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