A. Yu. Usanyov, S. M. Sukoreva, N. V. Prokopova, M. A. Gradova, N. Yu. Karpechenko, N. A. Bragina, K. A. Zhdanova, “Synthesis and photophysical properties of a new glycoconjugate based on <em>meso</em>-arylporphyrin”, Mendeleev Commun., 2025, Volume 35, Issue 6,Pages <nobr>667–669</nobr>

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Mendeleev Commun., 2025 Volume 35, Issue 6, Pages 667–669 (Mi mendc7306)

Communications

Synthesis and photophysical properties of a new glycoconjugate based on meso-arylporphyrin

A. Yu. Usanyov^a, S. M. Sukoreva^a, N. V. Prokopova^a, M. A. Gradova^b, N. Yu. Karpechenko^cd, N. A. Bragina^a, K. A. Zhdanova^a

^a M. V. Lomonosov Institute of Fine Chemical Technologies, MIREA – Russian Technological University, 119571 Moscow, Russian Federation
^b N. N. Semenov Federal Research Center for Chemical Physics, Russian Academy of Sciences, 119991 Moscow, Russian Federation
^c N. N. Blokhin National Medical Research Center of Oncology, 115522 Moscow, Russian Federation
^d N. I. Pirogov Russian National Research Medical University, 117997 Moscow, Russian Federation

Abstract: New conjugate of meso-aryl-substituted porphyrin and 2-deoxy-D-glucose was synthesized via the Cu-catalyzed azide–alkyne cycloaddition between azido-containing sugar and tetraethynyl-substituted porphyrin. The conjugate exhibits nanomolar photoinduced toxicity, namely, the IC₅₀ for MCF7 cells is 42 nM, and the IC₅₀ dark/IC₅₀ light ratio is 71.

Keywords: synthesis, meso-arylporphyrins, 2-deoxy-D-glucose, click reaction, antitumor activity, photodynamic therapy, photosensitizer.

Received: 04.04.2025
Accepted: 29.05.2025

Language: English

DOI: 10.71267/mencom.7791

	*Supplementary materials:*
		Supplementary_data_1.pdf	2.0 Mb

© Steklov Math. Inst. of RAS, 2025