E. Yu. Schmidt, N. V. Semenova, E. A. Golub', I. A. Ushakov, B. A. Trofimov, “Acetylene-driven superbase-mediated self-organization of (het)arylpyridines from (het)aromatic nitriles”, Mendeleev Commun., 2025, Volume 35, Issue 6,Pages <nobr>636

Communications

Acetylene-driven superbase-mediated self-organization of (het)arylpyridines from (het)aromatic nitriles

E. Yu. Schmidt, N. V. Semenova, E. A. Golub', I. A. Ushakov, B. A. Trofimov

A. E. Favorsky Irkutsk Institute of Chemistry, Siberian Branch of the Russian Academy of Sciences, 664033 Irkutsk, Russian Federation

Abstract: Acetylene gas reacts with (het)aromatic nitriles in the KOH/DMSO/MeOH superbase composition at 90 °C for 10 min to afford 2-(het)arylpyridines in up to 36% yield. The process can be rationalized as the self-organization of two molecules of acetylene and one molecule of nitrile.

Keywords: acetylenes, nitriles, pyridines, superbases, synthetic methods.

Received: 15.04.2025
Accepted: 07.05.2025

Language: English

DOI: 10.71267/mencom.7801

	*Supplementary materials:*
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