I. S. Aniskin, M. A. Shandybo, S. A. Kuznetsova, K. O. Biriukov, M. M. Ilyin Jr., M. G. Ezernitskaya, S. P. Kutumov, A. S. Poghosyan, A. S. Saghyan, V. P. Chernyshev, D. A. Chusov, Yu. N. Belokon, “Chiral hydrogen-bonded frameworks featuring proline motifs as heterogeneous catalysts for the enantioselective synthesis of warfarin”, Mendeleev Commun., 2025, Volume 35, Issue 6,Pages <nobr>642–644</nobr>

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Mendeleev Commun., 2025 Volume 35, Issue 6, Pages 642–644 (Mi mendc7326)

Communications

Chiral hydrogen-bonded frameworks featuring proline motifs as heterogeneous catalysts for the enantioselective synthesis of warfarin

I. S. Aniskin^a, M. A. Shandybo^ab, S. A. Kuznetsova^a, K. O. Biriukov^a, M. M. Ilyin Jr.^a, M. G. Ezernitskaya^a, S. P. Kutumov^a, A. S. Poghosyan^c, A. S. Saghyan^c, V. P. Chernyshev^d, D. A. Chusov^a, Yu. N. Belokon^a

^a A. N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, 119334 Moscow, Russian Federation
^b National Research University Higher School of Economics (HSE University), 101000 Moscow, Russian Federation
^c Scientific and Production Center ‘Armbiotechnology’, National Academy of Sciences of Republic Armenia, 0056 Yerevan, Armenia
^d JSC ‘Shchelkovo Agrokhim’, 141101 Shchelkovo, Moscow Region, Russian Federation

Abstract: Chiral hydrogen-bonded organic frameworks incorporating proline motifs were synthesized from tetrakis-, bis- or monoprolinamide precursors and di- or tetracarboxylic or sulfonic acids. Their testing as heterogeneous catalysts for the synthesis of warfarin provided product yields of up to 84% with ee values of up to 45%.

Keywords: heterogeneous catalysis, hydrogen-bonded organic frameworks, asymmetric catalysis, chiral tetraamines, warfarin, proline.

Received: 09.04.2025
Accepted: 17.06.2025

Language: English

DOI: 10.71267/mencom.7796

	*Supplementary materials:*
		Supplementary_data_1.pdf	2.2 Mb

© Steklov Math. Inst. of RAS, 2025