V. A. Pogorilyy, V. I. Efimova, J. S. Kartava, S. I. Tikhonov, M. N. Usachev, M. A. Grin, “A novel natural chlorin metal complex containing gold(I) in the macrocycle periphery”, Mendeleev Commun., 2025, Volume 35, Issue 6,Pages <nobr>664

Communications

A novel natural chlorin metal complex containing gold(I) in the macrocycle periphery

V. A. Pogorilyy, V. I. Efimova, J. S. Kartava, S. I. Tikhonov, M. N. Usachev, M. A. Grin

M. V. Lomonosov Institute of Fine Chemical Technologies, MIREA – Russian Technological University, 119571 Moscow, Russian Federation

Abstract: An original synthesis of methyl ester of 13¹-thioketone pyropheophorbide A containing a gold(I) complex at the periphery of the macrocycle (at the E exocycle) via the formation of an S–Au bond is performed. The stability of this complex in aqueous solutions at various pH values as well as the effectiveness of its binding to DNA are evidenced.

Keywords: pheophorbide, chlorophyll A, thiocarbonyl compounds, sulfur-containing compounds, gold(I) complexes, combined action.

Received: 25.04.2025
Accepted: 02.06.2025

Language: English

DOI: 10.71267/mencom.7810

	*Supplementary materials:*
		Supplementary_data_1.pdf	610.4 Kb