V. V. Spiridonov, K. S. Sadovnikov, D. A. Vasilenko, K. N. Sedenkova, A. R. Lukmanova, A. A. Markova, A. V. Shibaeva, A. V. Bolshakova, S. S. Karlov, E. B. Averina, A. A. Yaroslavov, “Synthesis and evaluation of the anticancer activity of the water-dispersible complexes of 4-acylaminoisoxazole derivative with biocompatible nanocontainers based on Ca2+ (Mg2+) cross-linked alginate”, Mendeleev Commun., 2022, Volume 32, Issue 5,Pages 591

This article is cited in 5 papers

Communications

Synthesis and evaluation of the anticancer activity of the water-dispersible complexes of 4-acylaminoisoxazole derivative with biocompatible nanocontainers based on Ca²⁺ (Mg²⁺) cross-linked alginate

V. V. Spiridonov^a, K. S. Sadovnikov^a, D. A. Vasilenko^a, K. N. Sedenkova^a, A. R. Lukmanova^b, A. A. Markova^cd, A. V. Shibaeva^c, A. V. Bolshakova^a, S. S. Karlov^a, E. B. Averina^a, A. A. Yaroslavov^a

^a Department of Chemistry, M.V. Lomonosov Moscow State University, Moscow, Russian Federation
^b Department of Materials Science, M.V. Lomonosov Moscow State University, Moscow, Russian Federation
^c N.M. Emanuel Institute of Biochemical Physics, Russian Academy of Sciences, Moscow, Russian Federation
^d A.N. Nesmeyanov Institute of Organoelement Compounds of Russian Academy of Sciences, Moscow, Russian Federation

Abstract: Water-dispersible complexes of 4-methyl-N-[5-methyl-3-(3,4,5-trimethoxyphenyl)isoxazol-4-yl]benzamide possessing anticancer activity were prepared by its immobilization with biocompatible polymer nanocontainers based on sodium alginate cross-linked with Ca²⁺ and Mg²⁺ ions. It was found that this isoxazole derivative retains its structure during immobilization. Colloidal stable nanocontainers filled with this compound exhibit toxicity toward the colon carcinoma (HCT116) tumor cell line.

Keywords: polysaccharide nanocontainers, alginate, 4-acylaminoisoxazoles, colloidal stability, anticancer activity.

Language: English

DOI: 10.1016/j.mencom.2022.09.007

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