V.-H. Nguyen, H. T. Phung, D. T. Doan, T. T. Do, “Highly cytotoxic palladium(ii) complexes with 1,2,4-triazole-derived carbene ligands”, Mendeleev Commun., 2022, Volume 32, Issue 5,Pages <nobr>594

This article is cited in 3 papers

Communications

Highly cytotoxic palladium(ii) complexes with 1,2,4-triazole-derived carbene ligands

V.-H. Nguyen^a, H. T. Phung^a, D. T. Doan^a, T. T. Do^b

^a Faculty of Chemistry, University of Science, Vietnam National University, Hanoi, Hoan Kiem, Hanoi, Vietnam
^b Institute of Biotechnology, Vietnam Academy of Science and Technology, Hanoi, Vietnam

Abstract: Two novel palladium(ii) complexes, trans-[PdBr₂(tz-Mes)₂] and trans-[PdBr₂(tz-Dipp)₂] featuring less explored 1,2,4-triazole-derived N-heterocyclic carbene (tz) have been synthesized. In solution, they exist both as trans-syn and trans-anti rotamers while their syn/anti ratios can be determined by ¹H NMR harnessing the built-in aromatic rings as NMR probes. Complex trans-[PdBr₂(tz-Mes)₂] is highly cytotoxic toward A549, MCF-7, LNCaP and HT-29 cancerous cells.

Keywords: 1,2,4-triazolin-5-ylidene ligands, palladium(ii) complexes, palladium-NHC, anticancer activities, NMR probe.

Language: English

DOI: 10.1016/j.mencom.2022.09.008

	*Supplementary materials:*
		Supplementary_data_1.pdf	630.8 Kb