N. A. Frolov, V. A. Smirnov, E. V. Detusheva, A. N. Vereshchagin, “Novel naphthalene-based bis-pyridinium compounds with pronounced antibacterial activity”, Mendeleev Commun., 2022, Volume 32, Issue 5,Pages <nobr>606

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Communications

Novel naphthalene-based bis-pyridinium compounds with pronounced antibacterial activity

N. A. Frolov^a, V. A. Smirnov^ab, E. V. Detusheva^c, A. N. Vereshchagin^a

^a N.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow, Russian Federation
^b D.Mendeleev University of Chemical Technology of Russia, Moscow, Russian Federation
^c State Research Center for Applied Microbiology & Biotechnology, Obolensk, Moscow Region, Russian Federation

Abstract: Novel para-substituted bis-pyridinium compounds containing 2,7-dioxynaphthalene spacer were synthesized in two simple steps from the corresponding dihydroxy-naphthalene. The microbiological study on five reference (E. coli ATCC 25922, K. pneumoniae ATCC 70060, S. aureus ATCC 43300, P. aeruginosa ATCC27853, and A. baumannii ATCC 15308) and five clinical (E. coli B-3421/19,K. pneumoniae B-2523/18, S. aureus B-8648, P. aeruginosa B-2099/18 and A. baumannii B-2926/18) bacterial strains showed promising range of antibacterial properties for these biocides, compared to modern sanitizers.

Keywords: quaternary bis-ammonium compounds, pyridinium compounds, alkylation, biological activity, antibacterial agents, biocides.

Language: English

DOI: 10.1016/j.mencom.2022.09.012

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