I. V. Grigoryan, G. B. Khomutov, A. N. Velikanov, A. P. Grigorian, L. V. Yakovenko, X. Huang, A. V. Sybachin, “Peculiarities of adsorption of nanocarriers on planar lipid surfaces”, Mendeleev Commun., 2026, Volume 36, Issue 3,Pages <nobr>305–307</nobr>

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Mendeleev Commun., 2026 Volume 36, Issue 3, Pages 305–307 (Mi mendc7446)

Communications

Peculiarities of adsorption of nanocarriers on planar lipid surfaces

I. V. Grigoryan^a, G. B. Khomutov^a, A. N. Velikanov^b, A. P. Grigorian^ac, L. V. Yakovenko^a, X. Huang^d, A. V. Sybachin^e

^a Department of Physics, M. V. Lomonosov Moscow State University, 199991 Moscow, Russian Federation
^b Department of Biology, M. V. Lomonosov Moscow State University, 199991 Moscow, Russian Federation
^c Institute of Biomedical Problems, Russian Academy of Sciences, 123007 Moscow, Russian Federation
^d School of Chemistry, Northeast Normal University, 5268 Changchun, China
^e Department of Chemistry, M. V. Lomonosov Moscow State University, 199991 Moscow, Russian Federation

Abstract: Modification of the surface of cationic liposomes with anionic cyclodextrin produced a colloidal liposome–cyclodextrin complex that retained a net positive charge. It was found that the adsorption efficiency of such nanocarriers on the surface of Langmuir lipid monolayers as biomimetics of planar lipid systems is significantly higher due to the formation of aggregates of the adsorbed complex.

Keywords: carboxymethyl cyclodextrin, liposome, lipid monolayer, interfacial complex, drug delivery, membrane rigidity.

Received: 05.11.2025
Accepted: 15.12.2025

Language: English

DOI: 10.71267/mencom.7960

	*Supplementary materials:*
		Supplementary_data_1.pdf	471.4 Kb

© Steklov Math. Inst. of RAS, 2026