A. T. Dang, N. T. Dao, D. T. Nguyen, A. A. Titov, H. T. Luong, V. N. Khrustalev, V. T. Tran, A. T. Le, “Three-component synthesis of new γ-piperidone-incorporating aza-14-crown-4 compounds”, Mendeleev Commun., Mi mendc7454

Communications

Three-component synthesis of new γ-piperidone-incorporating aza-14-crown-4 compounds

A. T. Dang^a, N. T. Dao^b, D. T. Nguyen^b, A. A. Titov^c, H. T. Luong^b, V. N. Khrustalev^cd, V. T. Tran^b, A. T. Le^b

^a Institute of Chemistry, Vietnam Academy of Science and Technology, 100000 Hanoi, Vietnam
^b Faculty of Chemistry, University of Science, Vietnam National University, 11021 Hanoi, Vietnam
^c Peoples Friendship University of Russia (RUDN University), 117198 Moscow, Russian Federation
^d N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 119991 Moscow, Russian Federation

Abstract: New aza-14-crown-4 compounds incorporating γ-piperidone unit have been prepared through the three-component reaction between dialdehyde podand, a ketone with two active methylene groups, and ammonium acetate or 2-phenylethylamine as nitrogen sources. Based on X-ray study, configuration of the products has been determined as rac-1S,21R,22S,24R.

Keywords: aza-14-crown-4 compounds, piperidone, Soldatenkov’s modification, tetracyclic compounds, X-ray study.

Received: 08.09.2025
Accepted: 26.01.2026

Language: English

DOI: 10.71267/mencom.7911