N. A. Sidlyaruk, A. V. Smolobochkin, A. S. Gazizov, N. I. Akylbekov, A. V. Zalaltdinova, T. S. Rizbayeva, A. P. Lyubina, A. R. Burilov, “Synthesis of phosphorus-containing proline analogs and assessment of their antitumor activity”, Mendeleev Commun., Mi mendc7456

Communications

Synthesis of phosphorus-containing proline analogs and assessment of their antitumor activity

N. A. Sidlyaruk^a, A. V. Smolobochkin^a, A. S. Gazizov^a, N. I. Akylbekov^b, A. V. Zalaltdinova^a, T. S. Rizbayeva^a, A. P. Lyubina^a, A. R. Burilov^a

^a Arbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center, Russian Academy of Sciences, 420088 Kazan, Russian Federation
^b Institute of Engineering and Technology, Korkyt Ata Kyzylorda University, 120014 Kyzylorda, Kazakhstan

Abstract: The Pudovik reactions of 3-arylidene-1-pyrrolinium tri fluoroacetates with hydrophosphoryl compounds in benzene at room temperature for 30 min afford phosphoryl containing proline analogs. The in vitro cytotoxicity studies indicate that the obtained compounds selectively inhibit HuTu 80 tumor cells growth and the activity of some of them is comparable to that of reference 5-fluorouracil.

Keywords: proline phosphoryl analogs, α-amino phosphonic acids, 3-arylidene-1-pyrroline, Pudovik reaction, antitumor activity.

Received: 08.12.2025
Accepted: 02.02.2026

Language: English

DOI: 10.71267/mencom.7980