M. E. Zhuravlev, K. Yu. Komarova, L. V. Khudiakova, M. V. Chudinov, A. Yu. Lukin, D. V. Dar’in, “Design and synthesis of spiro-linked azacycloalkane–dihydropyrano[4,3-<em>d</em>]pyrimidine compounds”, Mendeleev Commun., Mi mendc7458

Communications

Design and synthesis of spiro-linked azacycloalkane–dihydropyrano[4,3-d]pyrimidine compounds

M. E. Zhuravlev^a, K. Yu. Komarova^a, L. V. Khudiakova^a, M. V. Chudinov^a, A. Yu. Lukin^a, D. V. Dar’in^b

^a M. V. Lomonosov Institute of Fine Chemical Technologies, MIREA – Russian Technological University, 119454 Moscow, Russian Federation
^b St. Petersburg State University, 198504 St. Petersburg, Russian Federation

Abstract: New dihydropyrano[4,3-d]pyrimidines bearing 7-positioned spiro-linked azacycloalkane moieties were obtained by the Prins spirocyclization of commercially available N-protected azacycloalkanones followed by the regiospecific condensation with dimethylformamide dimethyl acetal and amidines. The new scaffold thus accessed appears to be a valuable building block for drug development.

Keywords: spiro compounds, pyrimidine synthesis, pyrano[4,3-d]pyrimidine, regiospecificity, drug design.

Received: 07.11.2025
Accepted: 12.01.2026

Language: English

DOI: 10.71267/mencom.7965