E. A. Titov, A. V. Nemtarev, A. D. Voloshina, A. P. Lyubina, V. F. Mironov, “Antitumor and antibacterial activity of novel menthyl- and bornyl-substituted 2-hydroxypropylphosphonium and arsonium salts”, Mendeleev Commun., Mi mendc7460

Communications

Antitumor and antibacterial activity of novel menthyl- and bornyl-substituted 2-hydroxypropylphosphonium and arsonium salts

E. A. Titov^a, A. V. Nemtarev^ab, A. D. Voloshina^b, A. P. Lyubina^b, V. F. Mironov^b

^a Kazan (Volga Region) Federal University, 420008 Kazan, Russian Federation
^b A. E. Arbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center of the Russian Academy of Sciences, 420088 Kazan, Russian Federation

Abstract: The reaction of (–)-menthyl/(–)-bornyl glycidyl ethers with H-triphenylphosphonium or H-triphenylarsonium triflates proceeds as a regioselective oxirane-opening at the terminal CH₂ fragment with the formation of the corresponding 2-hydroxy-3-terpenyloxypropylphosphonium or arsonium triflates. The salts thus prepared demonstrate high antimicrobial (MIC 1.9–3.9 μM S. aureus) and antitumor (IC₅₀ 0.1–1.1 μM HuTu 80) activities.

Keywords: menthol, borneol, glycidyl ethers, phosphonium salts, arsonium salts, antitumor activity, antimicrobial activity.

Received: 17.12.2025
Accepted: 09.02.2026

Language: English

DOI: 10.71267/mencom.7986