E. A. Nikitin, S. N. Klyukina, L. D. Popov, A. A. Moiseeva, V. A. Tafeenko, Yu. A. Gracheva, D. S. Yakovlev, M. S. Pshenichnikova, A. A. Spasov, E. R. Milaeva, “Redox-active salicylidenehydrazide analogues of vitamin E: synthesis, antioxidant and cytotoxic properties”, Mendeleev Commun., Mi mendc7479

Communications

Redox-active salicylidenehydrazide analogues of vitamin E: synthesis, antioxidant and cytotoxic properties

E. A. Nikitin^a, S. N. Klyukina^a, L. D. Popov^b, A. A. Moiseeva^a, V. A. Tafeenko^a, Yu. A. Gracheva^a, D. S. Yakovlev^c, M. S. Pshenichnikova^c, A. A. Spasov^c, E. R. Milaeva^a

^a Department of Chemistry, M. V. Lomonosov Moscow State University, 119991 Moscow, Russian Federation
^b Department of Chemistry, Southern Federal University, 344091 Rostov-on-Don, Russian Federation
^c Volgograd State Medical University, 400131 Volgograd, Russian Federation

Abstract: New vitamin E hydrazone analogues bearing (2-hydroxyaryl) methylene moieties were obtained from Trolox hydrazide and the corresponding 2-hydroxyarenecarbaldehydes. The compounds demonstrated effective antioxidant activity and selective action against cancer cells, suggesting their potential as supportive pharmacological agents in oncology.

Keywords: radioprotectors, antioxidants, Trolox, vitamin E, hydrazones, hydrazides, electrochemistry, cyclic voltammetry, cytotoxicity.

Received: 29.12.2025
Accepted: 11.03.2026

Language: English

DOI: 10.71267/mencom.7992