M. A. Orlova, V. V. Spiridonov, G. A. Badun, T. P. Trofimova, A. P. Orlov, A. S. Zolotova, A. B. Priselkova, G. Yu. Aleshin, M. G. Chernysheva, A. A. Yaroslavov, S. N. Kalmykov, “In vivo behavior of carboxymethylcellulose based microgels containing 67Cu”, Mendeleev Commun., 2022, Volume 32, Issue 5,Pages 658

This article is cited in 6 papers

Communications

In vivo behavior of carboxymethylcellulose based microgels containing ⁶⁷Cu

M. A. Orlova^ab, V. V. Spiridonov^a, G. A. Badun^a, T. P. Trofimova^a, A. P. Orlov^a, A. S. Zolotova^a, A. B. Priselkova^c, G. Yu. Aleshin^a, M. G. Chernysheva^a, A. A. Yaroslavov^a, S. N. Kalmykov^a

^a Department of Chemistry, M.V. Lomonosov Moscow State University, Moscow, Russian Federation
^b N.I. Pirogov Russian National Research Medical University, Moscow, Russian Federation
^c D.V. Skobeltsyn Institute of Nuclear Physics, M.V. Lomonosov Moscow State University, Moscow, Russian Federation

Abstract: Using a mouse model, an organ distribution for microgels of carboxymethyl cellulose cross-linked with ⁶⁷Cu²⁺ ions was investigated and compared with the distribution of free ⁶⁷Cu²⁺ ions from ⁶⁷CuCl₂. The clearance of the microgels through both liver and kidneys was demonstrated. An additional examination of distribution for [³H]CMC microparticles and [³H]CMC–Cu microgels revealed no copper release from the microgels in vivo.

Keywords: carboxymethyl cellulose, microgel, ⁶⁷Cu, tritium, mouse model, organ distribution, radiation stability.

Language: English

DOI: 10.1016/j.mencom.2022.09.030

	*Supplementary materials:*
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