A. R. Egorov, M. N. Kurasova, O. Khubiev, N. A. Bogdanov, A. G. Tskhovrebov, A. A. Kirichuk, V. N. Khrustalev, V. V. Rubanik, V. V. Rubanik, A. S. Kritchenkov, “Ciprofloxacin chitosan conjugate: combined antibacterial effect and low toxicity”, Mendeleev Commun., 2022, Volume 32, Issue 6,Pages <nobr>774

This article is cited in 6 papers

Communications

Ciprofloxacin chitosan conjugate: combined antibacterial effect and low toxicity

A. R. Egorov^a, M. N. Kurasova^a, O. Khubiev^a, N. A. Bogdanov^a, A. G. Tskhovrebov^a, A. A. Kirichuk^a, V. N. Khrustalev^ab, V. V. Rubanik^c, V. V. Rubanik^c, A. S. Kritchenkov^ac

^a Peoples Friendship University of Russia (RUDN University), Moscow, Russian Federation
^b N.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow, Russian Federation
^c Institute of Technical Acoustics, National Academy of Sciences of Belarus, Vitebsk, Republic of Belarus

Abstract: Ultrasound-mediated reaction of chitosan with ciprofloxacin in the presence of N,N'-dicyclohexylcarbodiimide in water gives the chitosan–ciprofloxacin conjugates of carboxamide type. The conjugates show a mediate antibacterial effect and reduced cytotoxicity.

Keywords: ciprofloxacin, chitosan, conjugates, carboxamides, ultrasound treatment, antibacterial activity, toxicity.

Language: English

DOI: 10.1016/j.mencom.2022.11.022

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