V. E. Shershov, V. E. Kuznetsova, R. A. Miftakhov, S. A. lapa, A. A. Stomahin, E. N. Timofeev, I. V. Grechishnikova, A. S. Zasedatelev, A. V. Chudinov, “Derivatization of a rigid <i>meso</i>-substituted heptamethine cyanine dye”, Mendeleev Commun., 2021, Volume 31, Issue 1,Pages <nobr>70

This article is cited in 4 papers

Communications

Derivatization of a rigid meso-substituted heptamethine cyanine dye

V. E. Shershov, V. E. Kuznetsova, R. A. Miftakhov, S. A. lapa, A. A. Stomahin, E. N. Timofeev, I. V. Grechishnikova, A. S. Zasedatelev, A. V. Chudinov

V.A. Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russian Federation

Abstract: A novel electroneutral rigid meso-sulfophenyloxy substituted heptamethine dye was synthesized in six steps. Selective derivatization of one sulfonamide group with octanedioic acid introduced the carboxy end group attached through the hexamethylene linker, which provided the dye solubility in water. Absorbance of the dye in the near infrared region makes it promising for covalent labeling of biomolecules.

Keywords: electroneutral dyes, cyanine dyes, heptamethine dyes, meso-sulfophenyloxy dyes, sulfonamides, acetylation, N-acylsulfonamides, fluorescently labeled nucleotides.

Language: English

DOI: 10.1016/j.mencom.2021.01.021

	*Supplementary materials:*
		Supplementary_data_1.pdf	1.1 Mb