S. N. Adamovich, E. Kh. Sadykov, I. A. Ushakov, E. N. Oborina, L. A. Belovezhets, “Antibacterial activity of new silatrane pyrrole-2-carboxamide hybrids”, Mendeleev Commun., 2021, Volume 31, Issue 2,Pages <nobr>204

This article is cited in 17 papers

Communications

Antibacterial activity of new silatrane pyrrole-2-carboxamide hybrids

S. N. Adamovich, E. Kh. Sadykov, I. A. Ushakov, E. N. Oborina, L. A. Belovezhets

A.E. Favorsky Irkutsk Institute of Chemistry, Siberian Branch of the Russian Academy of Sciences, Irkutsk, Russian Federation

Abstract: Silatrane-1H-pyrrole-2-carboxamide hybrids conjugated via propane-1,3-diyl linker have been synthesized by the reaction of 1-(3-aminopropyl)silatrane with 2-(trichloroacetyl)pyrroles. Their in silico screening would predict their antitumor activity. Their in vitro screening for antimicrobial activity revealed the representative with R¹=R²=R³=H to be the most potent against Gram-positive microorganisms such as E. durans, B. subtilis and E. coli.

Keywords: silatranes, pyrrolecarboxamides, hybrids, antitumor activity, antimicrobial action.

Language: English

DOI: 10.1016/j.mencom.2021.03.019

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