N. E. Borisova, M. A. Orlova, V. A. Knizhnikov, V. K. Dolgova, M. D. Reshetova, A. P. Orlov, “First <sup>97</sup>Ru complex with pyridine-2,6-dicarboxamide conjugate for potential use as radiopharmaceutical”, Mendeleev Commun., 2021, Volume 31, Issue 2,Pages <nobr>207

This article is cited in 8 papers

Communications

First ⁹⁷Ru complex with pyridine-2,6-dicarboxamide conjugate for potential use as radiopharmaceutical

N. E. Borisova^a, M. A. Orlova^ab, V. A. Knizhnikov^c, V. K. Dolgova^a, M. D. Reshetova^a, A. P. Orlov^a

^a Department of Chemistry, M.V. Lomonosov Moscow State University, Moscow, Russian Federation
^b N.I. Pirogov Russian National Research Medical University, Moscow, Russian Federation
^c Institute of Physical Organic Chemistry, National Academy of Sciences of Belarus, Minsk, Belarus

Abstract: A new peptidomimetic conjugate of natural methionine and pyridine-2,6-dicarboxylate was synthesized and evaluated as a potential ligand for ⁹⁷Ru radiopharmaceuticals. The distribution of this radiopharmaceutical in mice was investigated. A fundamental difference was found in the distribution and excretion of ruthenium complex and free ruthenium ion in the body, which suggests a difference in their transport pathways due to the stability of the complex in the body.

Keywords: ruthenium-97, mouse model, clearance, pyridine-2,6-dicarboxamide, conjugates, radioactivity.

Language: English

DOI: 10.1016/j.mencom.2021.03.020

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