E. A. Nikiforova, N. F. Kirillov, D. V. Baibarodskikh, S. N. Shurov, M. V. Dmitriev, D. P. Zverev, “Reaction of Reformatsky reagents with 2,5-diphenyl-1,3,4-oxadiazole”, Mendeleev Commun., 2021, Volume 31, Issue 2,Pages <nobr>248

This article is cited in 1 paper

Communications

Reaction of Reformatsky reagents with 2,5-diphenyl-1,3,4-oxadiazole

E. A. Nikiforova, N. F. Kirillov, D. V. Baibarodskikh, S. N. Shurov, M. V. Dmitriev, D. P. Zverev

Department of Chemistry, Perm State National Research University, Perm, Russian Federation

Abstract: The reaction of methyl a-bromoisobutyrate or 1-bromocycloalkanecarboxylates with zinc and 2,5-diphenyl-1,3,4-oxadiazole leads to 5-phenyl-2,4-dihydro-3H-pyrazol-3-one derivatives, with the cycloalkane series affording products of spiro structure. In the case of cyclobutane reactant, 3-phenyl-2,4,5,6-tetrahydropyrano[2,3-c]pyrazole is also formed.

Keywords: Reformatsky reaction, alicyclic compounds, organozinc compounds, 1,3,4-oxadiazoles, spiro compounds, pyrazol-3-ones, pyrano[2,3-c]pyrazoles, X-ray analysis.

Language: English

DOI: 10.1016/j.mencom.2021.03.035

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