A. N. Vereshchagin, N. A. Frolov, A. P. Minaeva, E. V. Detusheva, Ya. V. Derkach, M. P. Egorov, “Synthesis and biological evaluation of novel cyanuric acid-tethered tris-pyridinium derivatives”, Mendeleev Commun., 2021, Volume 31, Issue 3,Pages <nobr>368

This article is cited in 9 papers

Communications

Synthesis and biological evaluation of novel cyanuric acid-tethered tris-pyridinium derivatives

A. N. Vereshchagin^a, N. A. Frolov^a, A. P. Minaeva^ab, E. V. Detusheva^c, Ya. V. Derkach^ab, M. P. Egorov^a

^a N.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow, Russian Federation
^b D.Mendeleev University of Chemical Technology of Russia, Moscow, Russian Federation
^c State Research Center for Applied Microbiology & Biotechnology, Obolensk, Moscow Region, Russian Federation

Abstract: Novel tris(4-alkylaminopyridin-1-ium) trichlorides with alkylcyanuric spacer were synthesized by quaternization of 4-alkylaminopyridines with tris(2-chloroethyl) cyanurate. The obtained compounds were evaluated for microbiological activity against five pathogenic bacterial strains (Escherichia coli, Klebsiella pneumoniae, Staphylococcus aureus, Acinobacter baumannii, Pseudomonas aeruginosa). The results indicate the presence of pronounced antibacterial properties in this group of compounds.

Keywords: tris-quaternary ammonium compounds, pyridinium salts, biological activity, antibacterial agents.

Language: English

DOI: 10.1016/j.mencom.2021.04.028

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