A. A. Chinarev, M. A. Sablina, R. A. Kunetsky, N. V. Shilova, S. M. Polyakova, A. S. Paramonov, J. Saha, N. V. Bovin, “Synthesis of spacer armed Kdn(2→6') and (2→3')-lactosamines for immunochemical research”, Mendeleev Commun., 2021, Volume 31, Issue 4,Pages <nobr>490

This article is cited in 5 papers

Communications

Synthesis of spacer armed Kdn(2→6') and (2→3')-lactosamines for immunochemical research

A. A. Chinarev^a, M. A. Sablina^a, R. A. Kunetsky^a, N. V. Shilova^a, S. M. Polyakova^a, A. S. Paramonov^a, J. Saha^b, N. V. Bovin^a

^a M.M. Shemyakin–Yu.A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russian Federation
^b Centre of Biomedical Research, Sanjay Gandhi Post-Graduate Institute of Medical Science, Lucknow, India

Abstract: Glycosylation of lactosamine acceptors with Kdn thioglycoside donors in the presence of NIS/TfOH as a promoter affords products with both α- and β-ketosidic linkage (2–6' or 2–3') between the Kdn and Gal residues. After deprotection, the synthesized trisaccharides and glycans containing Neu5Ac were printed to a chip and their comparative interaction with human serum antibodies was explored.

Language: English

DOI: 10.1016/j.mencom.2021.07.017

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