J. Sun, L. He, Yu. Gao, L. Zhai, J. Ji, Yu. Liu, J. Ji, X. Ma, Ya. Mu, D. Tang, H. Yang, Z. Iqbal, Zh. Yang, “Synthesis of substituted-amidine derivatives of avibactam and synergistic antibacterial activity with meropenem”, Mendeleev Commun., 2021, Volume 31, Issue 4,Pages <nobr>498

This article is cited in 10 papers

Communications

Synthesis of substituted-amidine derivatives of avibactam and synergistic antibacterial activity with meropenem

J. Sun^a, L. He^a, Yu. Gao^a, L. Zhai^a, J. Ji^a, Yu. Liu^a, J. Ji^a, X. Ma^b, Ya. Mu^a, D. Tang^a, H. Yang^a, Z. Iqbal^a, Zh. Yang^a

^a Ningxia Centre of Organic Synthesis and Engineering Technology, Ningxia Academy of Agriculture and Forestry Sciences, Yinchuan, Ningxia, P.R. China
^b College of Pharmacy, Ningxia Medical University, Yinchuan, Ningxia, P.R. China

Abstract: New avibactam derivatives in which amide moiety is replaced by substituted amidine groupings were obtained in several steps, the key step having involved the conversion of 2-positioned cyano group of the 1,6-diazabicyclo[3.2.1]-octane framework into the amidine one. Synergistic antibacterial activity of the new compounds in combination with meropenem infers the agonistic effect of these derivatives against β-lactamases.

Language: English

DOI: 10.1016/j.mencom.2021.07.020

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